HLA/Linkage Disequilibrium/DR-DQ Blocks

< HLA < Linkage Disequilibrium

(Block frequency is expressed as the negative of the decimal logarithm of the frequency, that is 1 is 1 in 10, 2 is 1 in 100, 3 is 1 in 1000, etc.)

DRB1 DRB345 DQA1 DQB1 NegLogFreq Notes
DRB1*01:01:01 - DQA1*01:01:01 DQB1*05:01:01:01 1.1
DRB1*01:01:01 - DQA1*01:02:01:01 DQB1*05:04 3
DRB1*01:02:01 - DQA1*01:01:01 DQB1*05:01:01:01 1.7
DRB1*01:03 - DQA1*01:01:01 DQB1*05:01:01:01 1.9
DRB1*01:03 - DQA1*05:05:01:01 DQB1*03:01:01:01 3
DRB1*03:01:01:01 DRB3*01:01:02:01 DQA1*05:01:01 DQB1*02:01:01 1.1 Associated with B8
DRB1*03:01:01:01 DRB3*02:02:01:01 DQA1*05:01:01 DQB1*02:01:01 1.7 Not associated with B8
DRB1*03:01:01:01 DRB3*01:01:02:01 DQA1*01:02:01:01 DQB1*06:02:01 3.2
DRB1*03:01:01:01 DRB3*01:01:02:01 DQA1*05:01:01 DQB1*03:01:01:01 3.5
DRB1*03:01:01:01 DRB3*02:01 DQA1*05:01:01 DQB1*02:01:01 3.5 Jewish (Rumania)
DRB1*03:02:01 DRB3*01:01:02:01 DQA1*04:01:01 DQB1*04:02 2.5 African
DRB1*03:02:01 DRB3*03:01:01 DQA1*04:01:01 DQB1*04:02 3.5 African
DRB1*04:01:01 DRB4*01:03:01:01 DQA1*03:03 DQB1*03:01:01:01 1.4 Associated with B*4402
DRB1*04:01:01 DRB4*01:03:01:01 DQA1*03:01:01 DQB1*03:02:01 1.4 Associated with B*1501
DRB1*04:01:01 DRB4*01:03:01:02N DQA1*03:01:01 DQB1*03:02:01 3
DRB1*04:01:01 DRB4*01:02 DQA1*03:03 DQB1*03:01:01:01 3.5
DRB1*04:02:01 DRB4*01:03:01:01 DQA1*03:01:01 DQB1*03:02:01 2 More in Jewish & Arab. Associated with B*3801.
DRB1*04:02:01 DRB4*01:03:01:02N DQA1*03:01:01 DQB1*03:02:01 3.5 More in Jewish & Arab.
DRB1*04:03:01 DRB4*01:03:01:01 DQA1*03:01:01 DQB1*03:02:01 1.9
DRB1*04:03:01 DRB4*01:03:01:01 DQA1*03:01:01 DQB1*03:04 2.8 Sardinians
DRB1*04:03:01 DRB4*01:03:01:01 DQA1*03:01:01 DQB1*03:05:01 2.8 Eastern Europe and Jewish.
DRB1*04:04:01 DRB4*01:03:01:01 DQA1*03:01:01 DQB1*03:02:01 1.4
DRB1*04:05:01 DRB4*01:03:01:01 DQA1*03:03 DQB1*03:02:01 2.1 Mediterranean & African
DRB1*04:05:01 DRB4*01:03:01:01 DQA1*05:05:01:01 DQB1*03:01:01:01 3 Sardinians
DRB1*04:05:01 DRB4*01:03:01:01 DQA1*03:03 DQB1*02:02 3 African & Jewish
DRB1*04:05:01 DRB4*01:03:01:01 DQA1*01:03:01:01 DQB1*05:03:01:01 3.5 Filipino
DRB1*04:05:01 DRB4*01:03:01:01 DQA1*03:03 DQB1*04:01:01 3.5
DRB1*04:06:01 DRB4*01:03:01:01 DQA1*03:01:01 DQB1*03:02:01 3.2 Asian
DRB1*04:06:01 DRB4*01:03:01:01 DQA1*03:03 DQB1*04:02 4 African
DRB1*04:07:01 DRB4*01:03:01:01 DQA1*03:01:01 DQB1*03:02:01 1.9 Native American
DRB1*04:07:01 DRB4*01:03:01:01 DQA1*03:03 DQB1*03:01:01:01 1.9 Caucasian & African
DRB1*04:08:01 DRB4*01:03:01:01 DQA1*03:03 DQB1*03:01:01:01 2.5
DRB1*04:08:01 DRB4*01:03:01:01 DQA1*03:03 DQB1*03:04 2.9 Czech
DRB1*04:09 DRB4*01:03:01:01 DQA1*03:03 DQB1*03:01:01:01 4
DRB1*04:10 DRB4*01:03:01:01 DQA1*03:01:01 DQB1*04:02 3.5 Asian
DRB1*04:10 DRB4*01:03:01:01 DQA1*03:01:01 DQB1*03:02:01 4
DRB1*04:11 DRB4*01:03:01:01 DQA1*03:01:01 DQB1*03:02:01 2.6 Asian & Native American
DRB1*07:01:01:01 DRB4*01:01:01:01 DQA1*02:01 DQB1*02:02 1.2
DRB1*07:01:01:01 DRB4*01:03:01:01 DQA1*02:01 DQB1*02:02 1.4
DRB1*07:01:01:01 DRB4*01:03:01:02N DQA1*02:01 DQB1*02:02 3.5
DRB1*07:01:01:01 DRB4*01:03:01:01 DQA1*02:01 DQB1*03:02:01 3.5
DRB1*08:01:01 - DQA1*04:01:01 DQB1*04:02 1.9 Caucasian
DRB1*08:01:01 DRB3*02:02:01:01 DQA1*04:01:01 DQB1*04:02 3.5
DRB1*08:02:01 - DQA1*04:01:01 DQB1*04:02 2.3 Asian & Native American
DRB1*08:03:02 - DQA1*06:01:01 DQB1*03:01:01:01 3.2 Europe. Peculiar DQ block found in Europe with DRB1*080302 and in Asia with DRB1*120201 – DRB3*030101.
DRB1*08:03:02 - DQA1*04:01:01 DQB1*06:01:01 3.5 Asian
DRB1*08:04:01 - DQA1*05:05:01:01 DQB1*03:19 African. DQA1*0505 needs confirmation, possibly it comes form the block DRB1*110201 - DRB3*0202 - DQA1*0505 - DQB1*0319.
DRB1*08:04:01 - DQA1*04:01:01 DQB1*03:01:01:01 2.6 African
DRB1*08:04:01 - DQA1*04:01:01 DQB1*04:02 3.2 Africa, Europe. Relatively to all DRB1*080401, this block is more common in Europe than in Africa. In Europe with B*5801 - Cw*0718. In Africa with B*8101 - Cw*1801. Associated with A*290201, regardless of the BC block.
DRB1*08:04:04 - DQA1*04:01:01 DQB1*04:02 Mexican. With B*4002 - Cw*0306.
DRB1*08:06 - DQA1*01:02:01:01 DQB1*06:02:01 2.9 African
DRB1*08:07 - DQA1*04:01:01 DQB1*04:02 3 South American Indian
DRB1*08:11 - DQA1*04:01:01 DQB1*04:02 3.5 Pacific North West Indians & Eskimos
DRB1*09:01:02 DRB4*01:03:01:01 DQA1*03:02 DQB1*03:03:02:01 2.1 Caucasian, Asian, North American Indians
DRB1*09:01:02 DRB4*01:01:01:01 DQA1*03:02 DQB1*02:02 2.7 African
DRB1*10:01:01 - DQA1*01:04:01:01 DQB1*05:01:01:01 2
DRB1*11:01:01 DRB3*02:02:01:01 DQA1*05:05:01:01 DQB1*03:01:01:01 1.3
DRB1*11:01:01 DRB3*01:01:02:01 DQA1*05:05:01:01 DQB1*03:01:01:01 3.2
DRB1*11:01:01 DRB3*02:02:01:01 DQA1*01:02:01:01 DQB1*05:01:01:01 3.5 Hispanic
DRB1*11:01:01 DRB3*02:02:01:01 DQA1*01:02:01:01 DQB1*06:03:01 4
DRB1*11:01:02 DRB3*02:02:01:01 DQA1*01:02:01:01 DQB1*06:02:01 3 African
DRB1*11:01:02 DRB3*03:01:01 DQA1*01:02:01:01 DQB1*05:02:01 3.5
DRB1*11:02:01 DRB3*02:10 DQA1*05:05:01:01 DQB1*03:01:01:01 4
DRB1*11:02:01 DRB3*03:01:01 DQA1*05:05:01:01 DQB1*03:01:01:01 4 African
DRB1*11:03 DRB3*02:02:01:01 DQA1*05:05:01:01 DQB1*03:01:01:01 2.4
DRB1*11:04:01 DRB3*02:02:01:01 DQA1*05:05:01:01 DQB1*03:01:01:01 1.5 Jewish and other populations
DRB1*11:04:01 DRB3*02:02:01:01 DQA1*01:03:01:01 DQB1*06:03:01 3 Exclusively Jewish
DRB1*11:04:01 DRB3*02:02:01:01 DQA1*01:02:01:01 DQB1*06:02:01 3.5
DRB1*11:12:01 DRB3*02:02:01:01 DQA1*05:05:01:01 DQB1*03:01:01:01 4
DRB1*11:14:01 DRB3*02:02:01:01 DQA1*05:05:01:01 DQB1*03:01:01:01 4
DRB1*11:15 DRB3*02:02:01:01 DQA1*05:05:01:01 DQB1*03:01:01:01 3.5
DRB1*11:42 DRB3*02:02:01:01 DQA1*05:05:01:01 DQB1*03:01:01:01 3.5
DRB1*12:01:01 DRB3*02:02:01:01 DQA1*05:05:01:01 DQB1*03:01:01:01 2.2 Caucasian & Asian
DRB1*12:01:01 DRB3*01:01:02:01 DQA1*01:04:01:01 DQB1*05:01:01:01 3 African
DRB1*12:01:01 DRB3*01:01:02:01 DQA1*03:02 DQB1*03:03:02:01 3.5 African?, Asian
DRB1*12:01:01 DRB3*02:02:01:01 DQA1*01:04:01:01 DQB1*05:01:01:01 4 African
DRB1*12:02:01 DRB3*03:01:01 DQA1*06:01:01 DQB1*03:01:01:01 2.8 Asia. Peculiar DQ block found in Europe with DRB1*080302 and in Asia with DRB1*120201 – DRB3*030101.
DRB1*13:01:01 DRB3*01:01:02:01 DQA1*01:03:01:01 DQB1*06:03:01 1.5
DRB1*13:01:01 DRB3*02:02:01:01 DQA1*01:03:01:01 DQB1*06:03:01 1.7
DRB1*13:01:01 DRB3*03:01:01 DQA1*01:02:01:01 DQB1*05:01:01:01 3.2
DRB1*13:01:01 DRB3*01:01:02:01 DQA1*01:02:01:01 DQB1*05:01:01:01 3.5
DRB1*13:01:01 DRB3*03:01:01 DQA1*01:02:01:01 DQB1*06:09 3.5
DRB1*13:01:01 DRB3*01:01:02:01 DQA1*01:03:01:01 DQB1*06:02:01 3.5
DRB1*13:01:01 DRB3*01:01:02:01 DQA1*03:02 DQB1*03:03:02:01 3.5
DRB1*13:01:01 DRB3*03:01:01 DQA1*01:02:01:01 DQB1*06:04:01 3.5
DRB1*13:02:01 DRB3*03:01:01 DQA1*01:02:01:01 DQB1*06:04:01 1.5
DRB1*13:02:01 DRB3*03:01:01 DQA1*01:02:01:01 DQB1*06:09 2.1
DRB1*13:02:01 DRB3*03:01:01 DQA1*01:02:01:01 DQB1*05:01:01:01 3
DRB1*13:02:01 DRB3*02:02:01:01 DQA1*01:02:01:01 DQB1*06:04:01 3.5
DRB1*13:03:01 DRB3*01:01:02:01 DQA1*05:05:01:01 DQB1*03:01:01:01 2
DRB1*13:03:01 DRB3*02:02:01:01 DQA1*02:01 DQB1*02:02 3.5 African
DRB1*13:04 DRB3*02:02:01:01 DQA1*05:05:01:01 DQB1*03:19 3.5 African
DRB1*13:05:01 DRB3*02:02:01:01 DQA1*05:05:01:01 DQB1*03:01:01:01 2.6 Jewish
DRB1*14:01:01 DRB3*02:01 DQA1*01:04:01:01 DQB1*05:03:01:01 3.2 Jewish
DRB1*14:02 DRB3*01:01:02:01 DQA1*05:03 DQB1*03:01:01:01 2.6 Native American & Asian
DRB1*14:02 DRB3*01:01:02:01 DQA1*05:03 DQB1*03:04 3.5
DRB1*14:02 DRB3*02:02:01:01 DQA1*05:03 DQB1*03:01:01:01 3.5
DRB1*14:04 DRB3*02:02:01:01 DQA1*01:04:01:01 DQB1*05:03:01:01 4 Indian
DRB1*14:05:01 DRB3*02:02:01:01 DQA1*01:04:01:01 DQB1*05:03:01:01 4 Oriental
DRB1*14:06:01 DRB3*01:01:02:01 DQA1*05:03 DQB1*03:01:01:01 2.3 Native American
DRB1*14:07:01 DRB3*02:02:01:01 DQA1*01:04:01:01 DQB1*05:03:01:01 3.5
DRB1*14:17 DRB3*01:01:02:01 DQA1*01:02:01:01 DQB1*06:04:01 3.5
DRB1*14:21 DRB3*01:01:02:01 DQA1*01:03:01:01 DQB1*06:03:01 3.5
DRB1*14:54 DRB3*02:02:01:01 DQA1*01:04:01:01 DQB1*05:03:01:01 1.6 Universal
DRB1*14:54 DRB3*02:02:01:01 DQA1*01:04:01:01 DQB1*05:02:01 3.2 Asian
DRB1*14:54 DRB3*02:02:01:01 DQA1*01:04:01:01 DQB1*06:02:01 3.5
DRB1*14:54 DRB3*02:02:01:01 DQA1*01:04:01:01 DQB1*05:01:01:01 3.5
DRB1*14:54 DRB3*02:03 DQA1*01:04:01:01 DQB1*05:03:01:01 4
DRB1*15:01:01:01 DRB5*01:01:01 DQA1*01:02:01:01 DQB1*06:02:01 1
DRB1*15:01:01:01 DRB5*01:01:01 DQA1*01:02:01:01 DQB1*06:03:01 2.3
DRB1*15:01:01:01 DRB5*01:01:01 DQA1*01:02:01:01 DQB1*05:02:01 2.8
DRB1*15:01:01:01 DRB5*01:01:01 DQA1*01:02:01:01 DQB1*06:04:01 3.5
DRB1*15:01:01:01 - DQA1*01:02:01:01 DQB1*06:02:01 3.5 B6763
DRB1*15:01:01:01 DRB5*01:01:02 DQA1*01:02:01:01 DQB1*06:02:01 4
DRB1*15:02:01 DRB5*01:02 DQA1*01:03:01:01 DQB1*06:01:01 2.2
DRB1*15:03:01:01 DRB5*01:01:01 DQA1*01:02:01:01 DQB1*06:02:01 2.2 African
DRB1*15:03:01:01 DRB5*01:01:01 DQA1*03:02 DQB1*06:03:01 3.5
DRB1*15:03:01:01 DRB5*01:01:01 DQA1*03:02 DQB1*02:02 3.5
DRB1*15:03:01:01 - DQA1*01:02:01:01 DQB1*06:02:01 3.5
DRB1*16:01:01 DRB5*02:02 DQA1*01:02:01:01 DQB1*05:02:01 1.9 Caucasian
DRB1*16:01:01 DRB5*01:01:01 DQA1*01:02:01:01 DQB1*05:02:01 4 Caucasian
DRB1*16:02:01 DRB5*01:01:01 DQA1*01:02:01:01 DQB1*05:02:01 SE Asia
DRB1*16:02:01 DRB5*02:02 DQA1*01:02:01:01 DQB1*05:02:01 2.6 African, Asian
DRB1*16:02:01 DRB5*02:02 DQA1*05:05:01:01 DQB1*03:01:01:01 2.6 American
DRB1*16:02:01 DRB5*02:03 DQA1*01:02:01:01 DQB1*05:02:01 3.5 Asian
DRB1*16:05:01 DRB5*02:02 DQA1*01:02:01:01 DQB1*05:02:01 3.5
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