Genetics/Course

< Genetics
This image shows the fluorescence labeling of all 24 human chromosomes in a fibroblast nucleus. Credit: Andreas Bolzer, Gregor Kreth, Irina Solovei, Daniela Koehler, Kaan Saracoglu, Christine Fauth, Stefan Müller, Roland Eils, Christoph Cremer, Michael R. Speicher, Thomas Cremer.

The course objective is to provide students with a thorough knowledge of genetics. At the end of the course, a student should have a well-rounded, thorough knowledge and some exposure to heredity and epigenetics, each as they apply to humans.

The course is built upon the ongoing research performed by geneticists around the world and benefits from learning resources available here at Wikiversity.

In line with the Wikiversity ideal of learning by doing are some sixteen laboratory opportunities, an equal number of problem sets at several levels, and participatory lessons.

To present a wide variety of concepts within genetics, there are about forty-eight lectures which are also partly articles as references from the scholarly literature are included to challenge the student and open doors to further curiosity.

The course material is layered from a secondary to a university or tertiary level, topped off with an introduction to research, some of which is here at Wikiversity.

The general subject area is biochemistry. But, this includes knowledge from phosphate biochemistry, chemistry, biology, botany, zoology, and other subjects.

Prerequisites

Although a working knowledge of proteomics and genomics is beneficial, most of the concepts presented only require an introduction to genetics. Additional learning resources where the student may increase their background knowledge while progressing through the course are provided.

Completion levels

This course is dynamic. Each component resource has a level of completion icon following it based on ≥ 100 kb equals 100%:

  1. This resource is a stub, which means that pretty well nothing has been done yet. 0-5%.
  2. This resource is just getting off the ground. Please feel welcome to help! 6-15%.
  3. Been started, but most of the work is still to be done - 16-30%.
  4. About halfway there. You may help to clarify and expand it - 31-45%.
  5. Almost complete, but you can help make it more thorough - 46-60%.
  6. Ready for testing by learners and teachers. Please begin! 61-75%.
  7. This resource is considered to be ready for use - 76-90%. R
  8. This resource has reached a high level of completion - 91-100%. C

Some of the lectures, especially from other departments or schools may not have a completion icon.

Other lectures may already be at 100 kbytes and will have no icon.

Lectures

Each set of three lectures are associated with the learning-by-doing laboratory experiences, mini-lectures plus quizzes for the student to test their learning progress with some additional information, 2-3 lengthier exams often referred to as 'hourlies' (may take an hour to work through at a timed pace), a mid-term exam which is all-encompassing for the first half, and a final exam over the entire course material. The examinations are designed to be taken iteratively as many times as the student desires to achieve a thorough working knowledge of the subject.

Here the lectures are listed alphabetically. A suggested sequence can be found in the course syllabus.

  1. Agriculture
  2. Anthropology
  3. Biochemistry
  4. Biology
  5. Blood
  6. Bones
  7. Botany
  8. Cartilage
  9. Chromatins
  10. Chromosomes
  11. Collagen
  12. Control groups
  13. Cytoskeletons
  14. Ecology
  15. Epigenetics
  16. Epigenomes
  17. Eukaryotes
  18. Evolution
  19. Exaptation
  20. Genes
  21. Genetics
  22. Gene promoter
  23. Gene transcriptions
  24. Genomes
  25. Genomics
  26. Genotypes
  27. Heredity
  28. Human DNA
  29. Human RNA
  30. Human teeth
  31. Mediator complex
  32. Melanocytes
  33. Molecular genetics
  34. Mutations
  35. Nucleotide synthesis
  36. Paleanthropology
  37. Paleontology
  38. Phenotypes
  39. Phosphate biochemistry
  40. Phosphate reactions
  41. Phospholipids
  42. Proteins
  43. Proteomics
  44. Radiation
  45. Regions
  46. Ribosomes
  47. Spaceflights
  48. TATA box
  49. Teeth
  50. Theory of genetics
  51. Transcription factors
  52. Transcription of A1BG
  53. What is a human?
  54. Zoology

Laboratories

For the course, any sixteen of the following labs should be completed.

Lessons

Problem sets

Quizzes

Hourlies

  1. Hourly - Lectures 1-16
  2. Hourly - Lectures 17-32
  3. Hourly - Lectures 33-48

Midterm examination

  1. Midterm quiz

Final examination

  1. Final quiz

Alternate examinations that include the supplemental lectures are available.

Research

Hypothesis:

  1. Including alternate hypotheses in these resources can be developed into laboratories.
  2. Registered students can develop user subpages for labs, quizzes, and lessons.

Control groups

This is an image of a Lewis rat. Credit: Charles River Laboratories.

The findings demonstrate a statistically systematic change from the status quo or the control group.

“In the design of experiments, treatments [or special properties or characteristics] are applied to [or observed in] experimental units in the treatment group(s).[1] In comparative experiments, members of the complementary group, the control group, receive either no treatment or a standard treatment.[2]"[3]

Proof of concept

Def. a “short and/or incomplete realization of a certain method or idea to demonstrate its feasibility"[4] is called a proof of concept.

Def. evidence that demonstrates that a concept is possible is called proof of concept.

The proof-of-concept structure consists of

  1. background,
  2. procedures,
  3. findings, and
  4. interpretation.[5]

See also

References

  1. ↑ Klaus Hinkelmann, Oscar Kempthorne (2008). Design and Analysis of Experiments, Volume I: Introduction to Experimental Design (2nd ed.). Wiley. ISBN 978-0-471-72756-9. http://books.google.com/?id=T3wWj2kVYZgC&printsec=frontcover.
  2. ↑ R. A. Bailey (2008). Design of comparative experiments. Cambridge University Press. ISBN 978-0-521-68357-9. http://www.cambridge.org/uk/catalogue/catalogue.asp?isbn=9780521683579.
  3. ↑ "Treatment and control groups, In: Wikipedia". San Francisco, California: Wikimedia Foundation, Inc. May 18, 2012. Retrieved 2012-05-31.
  4. ↑ "proof of concept, In: Wiktionary". San Francisco, California: Wikimedia Foundation, Inc. November 10, 2012. Retrieved 2013-01-13.
  5. ↑ Ginger Lehrman and Ian B Hogue, Sarah Palmer, Cheryl Jennings, Celsa A Spina, Ann Wiegand, Alan L Landay, Robert W Coombs, Douglas D Richman, John W Mellors, John M Coffin, Ronald J Bosch, David M Margolis (August 13, 2005). "Depletion of latent HIV-1 infection in vivo: a proof-of-concept study". Lancet 366 (9485): 549-55. doi:10.1016/S0140-6736(05)67098-5. http://www.ncbi.nlm.nih.gov/pmc/articles/PMC1894952/. Retrieved 2012-05-09.

External links

This is a research project at http://en.wikiversity.org

Development status: this resource is experimental in nature.
Educational level: this is a research resource.
Resource type: this resource is a course.
Subject classification: this is a biochemistry resource.
Subject classification: this is a genetics resource.
Subject classification: this is a medicine resource.
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