Radiation Oncology/Pancreatic Endocrine Neoplasm

Pancreatic Endocrine Neoplasms (PEN)

Uncommon tumors, incidence ~4/1,000,000
Can be either functional or nonfunctional; common functional tumors include insulinoma and gastrinoma (giving rise to Zollinger-Ellison Syndrome (ZES))
European Neuroendocrine Society suggests TNM staging and grade are predictive of tumor behavior
Treatment for localized PENs is surgical resection or enucleation
Lymph node status important prognostic factor, so LND should be considered, especially since tumor size does not correlate with LN status
Low grade tumors have excellent long-term outcomes, 5-year OS >90%
Intermediate grade tumors with LN+ or DM+ have 5-year OS ~58%

This article is issued from Wikibooks. The text is licensed under Creative Commons - Attribution - Sharealike. Additional terms may apply for the media files.