Radiation Oncology/Breast/Male breast cancer

Breast Cancer in Men

Background

References: PMID 18042939

• Male breast cancer accounts for <1% of all breast cancer cases in the US.
• BRCA2:
  • Overall, 14% risk of being BRCA2+ (unselected patients with male breast cancer)
  • Risk of BRCA2+ in 77% in men with breast cancer in families with hereditary breast cancer
  • Risk for development of breast cancer in BRCA2+ man: 6.3% by age 70 ^[1]; 2.8% by age 70 and 6.9% by 80^[2]; relative risk of 102^[3]
• BRCA1:
  • Association is less clear than with BRCA2

Epidemiology

• MSKCC, 1999 (1973-94) PMID 10463981 -- "Localized male breast carcinoma and family history. An analysis of 142 patients." (Hill A, Cancer. 1999 Sep 1;86(5):821-5.)
  • 142 pts treated at MSKCC or Ochsner Clinic.
  • 5-year OS 86%, 10-yr 64%.
  • 15% of pts had a 1st degree relative with breast cancer.
  • Conclusion: Family history did not affect the age at diagnosis, duration of symptoms, the stage, or survival.

BRCA mutations

• NCI, 2007 PMID 18042939 -- "Breast cancer risk among male BRCA1 and BRCA2 mutation carriers." (Tai YC, J Natl Cancer Inst. 2007 Dec 5;99(23):1811-4.)
  • Retrospective. 97 men with breast cancer identified in multicenter database of families with BRCA1 or BRCA2 mutations.
  • Male BRCA1 carriers: cumulative risk of breast cancer by age 70 of 1.2%
  • BRCA2: cumulative risk by age 70 of 6.8%

Retrospective series

• MSKCC,1999 - PMID 10463981
  • see above under Epidemiology

• Princess Margaret, 1999 (1955-96) PMID 10091736 -- "Male breast carcinoma: a review of 229 patients who presented to the Princess Margaret Hospital during 40 years: 1955-1996." (Goss PE, Cancer. 1999 Feb 1;85(3):629-39.)
  • Retrospective. 229 pts over a 42 yr period. 5-yr DFS 47%, OS 53%, LC 91%

References