Telavancin
General
- Type: Glycopeptide antibiotic active against MRSA
- Dosage Forms: IV
- Common Trade Names: Vibativ
Adult Dosing
- 10 mg/kg IV q24hr
Pediatric Dosing
Special Populations
- Pregnancy Rating: C
- Lactation: Unknown
- Renal Dosing
- CrCl 30-50 mL/minute: 7.5 mg/kg IV q24hr
- CrCl 10-29 mL/minute: 10 mg/kg IV q48hr
- Pediatric
- Hepatic Dosing
- Adult
- Pediatric
Contraindications
- Allergy to class/drug
- Concomitant use of IV heparin
Adverse Reactions
Serious
- Renal impairment
- C. diff colitis
- Prolonged QT
Common
- Nausea/vomiting, diarrhea, taste disturbance
- Foamy urine
- Dizziness
- Rigors
- Pruritus, rash
Pharmacology
- Half-life: 8hr
- Metabolism:
- Excretion: Urine
- Mechanism of Action: Lipoglycopeptide antibiotic that is a synthetic derivative of vancomycin; inhibits bacterial cell wall synthesis by interfering with polymerization and cross-linking of peptidoglycan
Antibiotic Sensitivities[1]
Key
- S susceptible/sensitive (usually)
- I intermediate (variably susceptible/resistant)
- R resistant (or not effective clinically)
- S+ synergistic with cell wall antibiotics
- U sensitive for UTI only (non systemic infection)
- X1 no data
- X2 active in vitro, but not used clinically
- X3 active in vitro, but not clinically effective for Group A strep pharyngitis or infections due to E. faecalis
- X4 active in vitro, but not clinically effective for strep pneumonia
See Also
References
- Sanford Guide to Antimicrobial Therapy 2014
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