Tamsulosin

Administration

Type: α-blocker
Dosage Forms:
Routes of Administration: oral
Common Trade Names: Flomax

Adult Dosing

0.4mg PO once daily or nightly

Urolithiasis

0.4mg PO QHS until stone expulsion

Pediatric Dosing

Safety/efficacy not established

Special Populations

Pregnancy Rating: B
Lactation risk: Infant risk cannot be ruled out

Renal Dosing

Adult: No adjustment for CrCl >10

Hepatic Dosing

Adult: No adjustment

Contraindications

Allergy to class/drug

Adverse Reactions

Serious

Retinal detachment
Priapism

Common

Headache, dizziness, insomnia, somnolence
Abnormal ejaculation
Rhinitis
Back pain

Pharmacology

Half-life: 9-15h
Metabolism: CYP3A4 and CYP2D6
Excretion: Mostly renal

Mechanism of Action

α-1A antagonist→ smooth muscle relaxation in bladder neck, prostate, urethra→ increased urine flow rate

Comments

See Also

EBQ:α-blockers for ureteral stone expulsion
Urolithiasis

References

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