Sotalol

General
  • Type: Beta blockers
  • Dosage Forms: Tab (80 mg, 120 mg, 160 mg, 240 mg); Injection
  • Common Trade Names: Sotalol

Adult Dosing

Ventricular arrhythmia, life-threatening
  • 80-160 mg PO q12h
    • Start: 80mg PO q 12h
    • Max: 640 mg/day
    • Taper over 1-2wk to D/C
  • 75-150 mg IV q12h
    • Start: 75 mg IV q12h
    • Max: 600 mg/day
    • Taper over 1-2wk to D/C

Pediatric Dosing

Ventricular arrhythmia, life-threatening
  • <2 yo
    • Dose based on BSA and age-specific factor
  • 2+ yo, PO
    • 90-180 mg/m^2/day PO divided TID
      • Start: 90mg/m^2/day
      • Max: 180mg/m^2/day
  • 2+ yo, IV
    • 84-168mg/m^2/day IV divided TID
      • Start: 84mg/m^2/day
      • Max: 168mg/m^2/day

Special Populations
  • Pregnancy Rating: Category B Caution advised (esp in 2nd and 3rd trimester)
  • Lactation: Possibly unsafe
  • Renal Dosing
    • Adult
      • CrCl 30-59: Give q24h
      • CrCl 10-29: Give q36-48h
      • CrCl <10: Individualize Dose
      • IV drug contraindicated with CrCl <40
    • Pediatric
      • Not defined
  • Hepatic Dosing
    • Adult
      • No Adjustment
    • Pediatric
      • No Adjustment

Indications
  • Suppression of ventricular arrhythmias refractory to other meds
  • Suppression of SVT, a-fib

Contraindications

Adverse Reactions

Serious

Common


Pharmacology
  • Half-life: 12h
  • Metabolism: None
  • Excretion: Urine
  • Mechanism of Action:
    • Class II - Nonselective beta-blocker
    • Class III effects (prolongs repol and refractoriness)
  • Onset of action = 2-3hr
  • Duration of action = 24hr

See Also

References
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