Streptococcus pneumoniae
Background
- Gram Positive cocci in clusters/pairs
- Asociated with pneumonia, meningitis, peritonitis and other severe infections
- Isolation of this organism is always significant and should be treated[1]
Antibiotic Sensitivities[2]
| Category | Antibiotic | Strep. Pneumoniae |
| Penicillins | Penicillin G | S |
| Penicillin V | S | |
| Methicillin | S | |
| Nafcillin/Oxacillin | S | |
| Cloxacillin/Diclox. | S | |
| Amino-Penicillins | AMP/Amox | S |
| Amox-Clav | S | |
| AMP-Sulb | S | |
| Anti-Pseudomonal Penicillins | Ticarcillin | S |
| Ticar-Clav | S | |
| Pip-Tazo | S | |
| Piperacillin | S | |
| Carbapenems | Doripenem | S |
| Ertapenem | S | |
| Imipenem | S | |
| Meropenem | S | |
| Aztreonam | R | |
| Fluroquinolones | Ciprofloxacin | I |
| Ofloxacin | I | |
| Pefloxacin | R | |
| Levofloxacin | S | |
| Moxifloxacin | S | |
| Gemifloxacin | S | |
| Gatifloxacin | S | |
| 1st G Cephalo | Cefazolin | S |
| 2nd G. Cephalo | Cefotetan | S |
| Cefoxitin | S | |
| Cefuroxime | S | |
| 3rd/4th G. Cephalo | Cefotaxime | S |
| Cefizoxime | S | |
| CefTRIAXone | S | |
| Ceftaroline | S | |
| CefTAZidime | S | |
| Cefepime | S | |
| Oral 1st G. Cephalo | Cefadroxil | S |
| Cephalexin | S | |
| Oral 2nd G. Cephalo | Cefaclor/Loracarbef | S |
| Cefproxil | S | |
| Cefuroxime axetil | S | |
| Oral 3rd G. Cephalo | Cefixime | S |
| Ceftibuten | I | |
| Cefpodox/Cefdinir/Cefditoren | S | |
| Aminoglycosides | Gentamicin | R |
| Tobramycin | R | |
| Amikacin | R | |
| Chloramphenicol | S | |
| Clindamycin | S | |
| Macrolides | Erythromycin | I |
| Azithromycin | I | |
| Clarithromycin | I | |
| Ketolide | Telithromycin | S |
| Tetracyclines | Doxycycline | S |
| Minocycline | S | |
| Glycylcycline | Tigecycline | S |
| Daptomycin | X4 | |
| Glyco/Lipoclycopeptides | Vancomycin | S |
| Teicoplanin | S | |
| Telavancin | S | |
| Fusidic Acid | I | |
| Trimethoprim | I | |
| TMP-SMX | S | |
| Urinary Agents | Nitrofurantoin | S |
| Fosfomycin | S | |
| Other | Rifampin | S |
| Metronidazole | R | |
| Quinupristin dalfoppristin | S | |
| Linezolid | S | |
| Colistimethate | R |
Key
- S susceptible/sensitive (usually)
- I intermediate (variably susceptible/resistant)
- R resistant (or not effective clinically)
- S+ synergistic with cell wall antibiotics
- U sensitive for UTI only (non systemic infection)
- X1 no data
- X2 active in vitro, but not used clinically
- X3 active in vitro, but not clinically effective for Group A strep pharyngitis or infections due to E. faecalis
- X4 active in vitro, but not clinically effective for strep pneumonia
Table Overview
See Also
References
- Antibiotic Therapy for Positive Blood Cultures. Perez-Jorge EV, et al. Antimicrobe. http://www.antimicrobe.org/new/e38rev2.asp
- Sanford Guide to Antimicrobial Therapy 2014
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