Open fracture
Background
- Fractures that have communication with the outside environment are considered open
- The fractured portion does not have to be overtly exposed
- True orthopedic emergency
Clinical Features
- Suspect open fracture with overlying wound regardless of how small
- Free air on x-ray may suggest open fracture in more equivocal cases
Differential Diagnosis
Evaluation
- ATLS
- X-ray
- Trauma labs
Gustilo-Anderson grading scale
As the grade increase, so does the risk of infection
Grade I
- Wound <1cm
- Little soft tissue injury or crush injury
- Moderately clean puncture site
- Infection risk 0-12%
Grade II
- Laceration >1cm
- No extensive soft tissue damage, but slight or moderate crush injury
- Moderate contamination
- Infection risk 2-12%
Grade III
- Extensive damage to soft tissue, including neurovascular structures and muscle
- High degree of contamination
- Infection risk 5-50%
- Further subcategorized:
- III A: Fracture covered by soft tissue (Infection risk 5-10%)
- III B: Loss of soft tissue and evidence of bone stripping (Infection risk 10-50%)
- III C: Any fracture with an associated arterial injury that requires surgical repair (Infection risk 25-50%)
Additional Considerations
- Fracture with non-communicating overlying wound
- Additional sites of injury found in 40-80% of cases
- Nerve, vascular, muscular, and/or ligamentous injury
Management
Prophylactic Antibiotics for Open fractures[1]
Initiate as soon as possible; increased infection rate when delayed for >3 hours from injury (NNT 12.5)[2]
Grade I & II Fractures Options
- 1st generation cephalosporin: e.g. Cefazolin (Ancef) 2g IV TID
- Allergy to above: Clindamycin or vancomycin (25mg/kg) IV
Grade III Fracture Options
- Treatment as above for Grade I/II
- PLUS aminoglycoside: e.g. Gentamicin 300 mg (1-1.7mg/kg) IV
- Once daily dosing has been shown to be safe and effective
Special Considerations
- Concern for Clostridium (soil contamination, farm injuries, possible bowel contamination): single drug regimen of Pipericillin/Tazobactam 4.5g (80mg/kg) IV TID
- Fresh water wounds: fluoroquinolones OR 3rd/4th generation cephalosporin
- Saltwater wounds: doxycycline + ceftazidime OR fluoroquinolone
Wound Managment [3]
- Surgical debridement and washout within 24 hours.
- Thorough ED irrigation and debridement appears safe for hand (metacarpal, phalanx) fractures without excessive contamination
- Irrigation may be started in the ED for grossly contaminated wounds
- Place a sterile dressing over wound to decrease continued contamination
- Tetanus prophylaxis
Disposition
Admission to ortho or trauma surgery
See Also
External Links
References
- Open Fractures, Prophylactic Antibiotic Use in — Update. https://www.east.org/education/practice-management-guidelines/open-fractures-prophylactic-antibiotic-use-in-update
- Gosselin RA, et al. Antibiotics for preventing infection in open limb fractures. Cochrane Database Syst Rev. 2004; (1):CD003764.
- Ketonis C, Dwyer J, Ilyas AM. Timing of Debridement and Infection Rates in Open Fractures of the Hand: A Systematic Review. Hand (N Y). 2017;12(2):119-126.
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