Mometasone

• Type: Inhaled corticosteroid
• Dosage Forms: 100, 200 mcg/actuation MDI
• Routes of Administration: Inhalation
• Common Trade Names: Asmanex HFA

• Prior medium dose inhaled steroid
  • 2 puffs (100 mcg/actuation) q 12h
    • Max: 800 mcg/day
    • Taper to lowest effective dose
• Prior high dose inhaled steroid
  • 2 puffs (200 mcg/actuation) q 12h
    • Max: 800 mcg/day
    • Taper to lowest effective dose
• Prior oral steorid
  • 2 puffs (200 mcg/actuation) q 12h
    • Max: 800 mcg/day
    • Taper to lowest effective dose. Taper oral steroids gradually after > 1wk

• 12+ yo, Prior medium dose inhaled steroid
  • 2 puffs (100 mcg/actuation) q 12h
    • Max: 800 mcg/day
    • Taper to lowest effective dose
• 12+ yo, Prior high dose inhaled steroid
  • 2 puffs (200 mcg/actuation) q 12h
    • Max: 800 mcg/day
    • Taper to lowest effective dose
• 12+ yo, Prior oral steorid
  • 2 puffs (200 mcg/actuation) q 12h
    • Max: 800 mcg/day
    • Taper to lowest effective dose. Taper oral steroids gradually after > 1wk

• Pregnancy Rating: C; Possible risk of teratogenicity based on animal data at 0.3-8x MRHD.
• Lactation risk: L3; Safety unknown

• Allergy to class/drug
• Asthma, acute
• Bronchospasm, acute
• Avoid abrupt withdrawal

• Half-life: 5h
• Metabolism: Liver; CYP450: 3A4 substrate
• Excretion: Feces 74%, Urine 8%

Exact mechanism of anti-inflammatory action unknown. Inhibits multiple inflammatory cytokines and produces multiple glucocorticoid and mineralcorticoid effects.