Lindane

• Type: Pediculicide
• Dosage Forms:
• Routes of Administration: topical
• Common Trade Names:

Second line therapy only for patients who have failed other agents

• Scabies: apply thin layer and massage on entire body except face, remove after 8-12h
• Head lice: apply 1-2 oz of shampoo on dry hair, leave on for 4min, lather/rinse and remove nits with fine comb

Second line therapy only for patients who have failed other agents Caution if patient weighs <50kg

• Scabies: apply thin layer and massage on entire body except face, remove after 8-12h
• Head lice: apply 1-2 oz of shampoo on dry hair, leave on for 4min, lather/rinse and remove nits with fine comb

• Allergy to class/drug
• Premature neonates (<28 do) (increased absorption)
• Uncontrolled seizure disorder
• Norwegian (crusted) scabies
• Skin conditions that may increase systemic absorption (weeping surface, inflamed skin etc)
• Caution with:
  • HIV infection
  • Prior seizure
  • Prior head trauma
  • CNS tumor
  • Severe hepatic cirrhosis
  • Excess alcohol use or abrupt withdrawal from alcohol or benzos
  • Concomitant use of meds that lower seizure threshold
  • Weight <50kg

• Half-life: 17-22h
• Metabolism: liver
• Excretion: urine and feces

• "Following absorption through the chitinous exoskeleton of arthropods, cyclic chlorinated hydrocarbons like lindane presumably stimulate the nervous system, resulting in seizures & death of parasite"[1]

• Black box for neurotoxicity, banned in several countries and California due to neurotoxicity

• Permethrin