Glyburide

Administration

Type: Sulfonylurea
Dosage Forms: Tab: 1.25mg, 2.5 mg, 5 mg
Routes of Administration: Oral
Common Trade Names: DiaBeta, Micronase

Adult Dosing

Diabetes mellitus, Type 2

1.25-20 mg/day PO divided qd-bid
- Max: 20mg/day

Pediatric Dosing

Safety/efficacy not established in pediatric patients

Special Populations

Pregnancy Rating: C
Lactation risk: Caution advised while breastfeding

Renal Dosing

Adult:
- CrCl <50: Avoid Use
Pediatric:
- No current guidelines

Hepatic Dosing

Adult:
- Start at 1.25 mg qd
Pediatric:
- No current guidelines

Contraindications

Allergy to class/drug
CrCl < 50
DKA
Diabetes mellitus, type 1

Adverse Reactions

Serious

Exfoliative dermatitis
Erythema multiforme
Hypoglycemia
Cholestatic jaundice
Hepatitis
Aplasic anemia, hemolytic anemia, pancytopenia, thrombocytopenia
Hyponatremia, SIADH
Disulfiram-like rxn

Common

Nausea, Dyspepsia
Blurred vision
Weight gain
Drowsiness
Rash

Pharmacology

Half-life: 10h
Metabolism: Liver; CYP2C9 substrate
Excretion: Bile 50%, Urine 50%

Mechanism of Action

Stimulates pancreatic islet beta cell insulin release

Comments

See Also

Diabetes Medications

References

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