Fever of unknown origin
This page is for adult patients. For pediatric patients, see: fever of unknown origin (peds)
Background
Clinical Features
Differential Diagnosis
- Infectious disease (22%)
- EBV
- UTI
- Enterovirus
- Lyme
- Cat-scratch disease
- Osteomyelitis
- Psittacosis
- Rheumatic fever
- Crohn's
- Bacterial meningitis
- Autoimmune (6%)
- JRA
- SLE
- PAN
- Malignancy (2%)
- Leukemia
- Lymphoma
- Drug-induced fever (2%)
- Factitious (2%)
- No Etiology (67%)
Evaluation
Workup
Phase 1
- CBC
- ESR
- TB test
- MonoSpot
- CXR
- blood culture
- ASLO
- ANA
- HIV
Phase 2
- LP
- blood culture again
- Sinus/mastoid x-ray
- Ophtho exam for iridocyclits
- CMV, Toxo, Hep A/B, Tularemia, Brucellosis, Leptospirosis, Salmonellosis
- LFTs
Phase 3
- Abd ultrasound
- Abd CT
- Gallium/Indium scanning
- UGI series with sbft
- Bone marrow
- Technetium bone scan
Management
Disposition
See Also
References
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