Fentanyl

General
  • Type: Opiods
  • Dosage Forms: IV, intranasal, transdermal
  • Common Trade Names: Sublimaze

Adult Dosing
  • Analgesia: 1-2 mcg/kg IV/IM, q30-60 min PRN
  • Sedation: 1-3 mcg/kg/hr continuous infusion

Pediatric Dosing
  • 0.5-2 mcg/kg IV/IN q1-2 hr

Special Populations[1]
  • Pregnancy Rating: C
  • Lactation: Excreted in breast milk, not recommended
  • Renal Dosing
    • Adult
      • Not defined
    • Pediatric
      • Not defined but recommendations for IV:
        • GFR > 50 mL/minute/1.73 m²: no adjustment
        • GFR 10 to 50 mL/minute/1.73 m²: 75% of usual dose
        • GFR < 10 mL/minute/1.73 m²: 50% of usual dose
        • Hemodialysis: 50% of usual dose
  • Hepatic Dosing
    • Adult
      • Not defined
    • Pediatric
      • Not defined

Contraindications
  • Allergy to class/drug

Adverse Reactions

Serious
  • Apnea

Common
  • Confusion
  • Constipation
  • Nausea/Vomiting
  • Somnolence
  • Sweating
  • Asthenia

Pharmacology
  • Half-life: 2-4 hours
  • Metabolism: Hepatic
  • Excretion: Renal
  • Mechanism of Action: Narcotic opiate receptor agonist

See Also

References
  1. Fentanyl: Drug information. UpToDate. www.uptodate.com. Accessed April 2, 2019.
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