Dapsone

Administration

Type: Antibiotic
Dosage Forms: 25,100
Routes of Administration: Oral

Adult Dosing

Hansen's disease (leprosy)

paucibacillary: 100mg PO QD x6mo
- Use with rifampin
multibacillary: 100mg PO QD x12mo
- Use with rifampin, clofazimine

Bullous pemphigoid

50mg PO QD
- Use with topical or systemic corticosteroids

Dermatitis herpetiformis

50mg PO QD

PCP

Prophylaxis: 100mg/day PO divided QD-bid
- Off label use
Treatment: 100mg PO QD x21 days
- Not 1st-line agent; use with trimethoprim
- Off label use

Malaria suppression

100mg PO qwk
- Use with pyrimethamine
- Off label use

Toxoplasmosis prophylaxis

50mg PO QD
- Off label use

Pediatric Dosing

Special Populations

Pregnancy Rating: C
Lactation risk: Probably unsafe

Renal Dosing

No adjustment

Hepatic Dosing

Caution advised with hepatic impairment
CBC qwk x4, qmo x6, then q6mo thereafter
LFTs at baseline, then periodically

Contraindications

Allergy to class/drug
caution if renal or hepatic impairment
caution if impaired cardiovascular function

Adverse Reactions

Serious

anemia, hemolytic
aplastic anemia
agranulocytosis
exfoliative dermatitis
erythema multiforme
toxic epidermal necrolysis

Common

fever
myalgia
headache
rigors
fatigue
malaise
dizziness

Pharmacology

Half-life: 28 hrs
Metabolism: Liver, CYP450
Excretion: Urine

Mechanism of Action

Comments

See Also

References

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