Chylothorax
Background
- Lymphatic fluid in pleural space
- Due to disruption or obstruction of the thoracic duct
- Differentiate from pseudocylothorax, a chronic cholesterol containing, chyliform pleural effusion not from thoracic duct disruption[1]
- Causes:
- Malignancy (50%), especially lymphoma
- Trauma (including iatrogenic)
- Cirrhosis
- Tuberculosis
- Sarcoidosis
- Amyloidosis
- Lymphatic filariasis
- Idiopathic
Differential Diagnosis
Emergent
- Pulmonary
- Airway obstruction
- Anaphylaxis
- Angioedema
- Aspiration
- Asthma
- Cor pulmonale
- Inhalation exposure
- Noncardiogenic pulmonary edema
- Pneumonia
- Pneumocystis Pneumonia (PCP)
- Pulmonary embolism
- Pulmonary hypertension
- Tension pneumothorax
- Idiopathic pulmonary fibrosis acute exacerbation
- Cystic fibrosis exacerbation
- Cardiac
- Other Associated with Normal/↑ Respiratory Effort
- Abdominal distension
- Anemia
- CO Poisoning
- Salicylate toxicity
- Diabetic ketoacidosis (DKA)
- Diaphragm injury
- Electrolyte abnormalities
- Epiglottitis
- Flail chest
- Hypotension
- Metabolic acidosis
- Pneumonia
- Pneumothorax/hemothorax
- Renal Failure
- Sepsis
- Toxic ingestion
- Other Associated with ↓ Respiratory Effort
Pediatric-specific
- Aspirated foreign body
- Respiratory distress syndrome
- Meconium aspiration syndrome
- Bronchiolitis (peds)
- Pertussis
- Bronchopulmonary dysplasia
- Croup
- Bacterial tracheitis
- Tracheomalacia
- Congenital heart disease
- Vascular ring
- Neonatal abstinence syndrome
- Inborn errors of metabolism
- Brief resolved unexplained event
- Normal neonatal periodic breathing (misinterpreted by caregivers as abnormal)
Non-Emergent
- ALS
- Ascites
- Uncorrected ASD
- Congenital heart disease
- COPD exacerbation
- Fever
- Hyperventilation
- Interstitial lung disease
- Neoplasm
- Obesity
- Panic attack
- Pleural effusion
- Polymyositis
- Porphyria
- Pregnancy
- Rib fracture
- Spontaneous pneumothorax
- Thyroid Disease
- URI
Evaluation
- CXR
- ECG
- CBC, BMP
- +/- BNP, D-dimer, Troponin to rule out other etiology
- +/- Bedside lung ultrasound
- Thoracentesis with classically white, odorless, milky fluid:
- Differentiate from empyema and pseudochylothorax
- In congenital chylothorax, pleural fluid is serous and becomes chylous when milk feedings start
- Pleural fluid analysis[2]:
- Triglycerides > 110 mg/dL
- Cholesterol
- LDH
- Chylomicron analysis
- Protein
- Culture and gram stain
- Cell differential and count
- Serum LDH, total cholesterol, and total protein comparison
- Ratio of pleural fluid : serum cholesterol < 1.0 in chylothorax
- In pseudochylothorax, this ratio will exceed 1.0[3]
Management
- Thoracic duct leaks close spontaneously in ~50% of patients[4]
- Treat underlying cause (e.g. chemoradiation for malignancy)
- Refractory: pleurodesis, thoracic duct ligation, pleuroperitoneal shunt, pleurectomy
Disposition
See Also
External Links
References
- Light RW . Chylothorax and pseudochylothorax. In: Pleural Diseases, 6th ed. Philadelphia, PA: Wolters Kluwer Lippincott Williams and Wilkins; 2013.
- Tutor JD. Chylothorax in Infants and Children. Pediatrics. April 2014, VOLUME 133 / ISSUE 4.
- Romero S, Martín C, Hernandez L, et al. Chylothorax in cirrhosis of the liver: analysis of its frequency and clinical characteristics. Chest. 1998;114(1):154–159.
- Bender B, Murthy V, Chamberlain RS. The changing management of chylothorax in the modern era. Eur J Cardiothorac Surg. 2016 Jan. 49 (1):18-24. [Medline]
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