Cephalosporins
1st Generation
- Skin and soft tissue infections (why is agent of choice before generalized symptoms)
- Cross-reactivity of PCN allergy <10%
2nd Generation
- Intestinal anaerobes (why is agent of choice for colorectal sx)
- Largely displaced by 3rd gen agents
3rd Generation
- Drug of choice for serious infections due to:
- Klebsiella
- Enterobacter
- Proteus
- Haemophilus
- Gonorrhea
- Lyme Disease
- Meningitis (+ vanc and ampicillin)
- Pseudomonas meningitis (+ AG)
4th Generation
- Resistant, nosocomial infections
References
Goodman & Gilman's Pharmacology
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