Ceftaroline

• Type: Antibiotic, Cephalosporin (fifth generation)
• Dosage Forms: IV
• Common Trade Names: Teflaro

• Pneumonia, Community-acquired: IV: 600 mg every 12 hours for 5 to 7 days
• Skin and skin structure infection: IV: 600 mg every 12 hours for 5 to 14 days

• Cystic Fibrosis pulmonary exacerbation, MRSA:
  • Children ≥ 6 years old - IV 15 mg/kg/dose every 8 hours (max dose 600 mg/dose)

• Pneumonia, community acquired:
  • ≥ 2 months - < 2 years age - IV 8 mg/kg/dose every 8 hours for 5-14 days
  • ≥ 2 years - < 18 years
    • ≤ 33 kg: IV 12 mg/kg/dose every 8 hours for 5-14 days
    • > 33 kg: IV 400 mg every 8 hours OR 600 mg every 12 hours for 5-14 days

• Skin and skin structure infection:
  • ≥ 2 months - < 2 years age - IV 8 mg/kg/dose every 8 hours
  • ≥ 2 years - < 18 years
    • ≤ 33 kg: IV 12 mg/kg/dose every 8 hours
    • > 33 kg: IV 400 mg every 8 hours OR 600 mg every 12 hours

• Pregnancy Rating:
  • Adverse events have been observed in animal studies
• Lactation:
  • Unknown if excreted in breast milk. Manufacturer recommends to use caution when giving to nursing women.
• Renal Dosing
  • Adult
    • CrCl > 50 mL/minute: No dosage adjustment necessary
    • CrCl > 30 to ≤ 50 mL/minute: 400 mg every 12 hours
    • CrCl ≥ 15 to ≤ 30 mL/minute: 300 mg every 12 hours
    • CrCl < 15 mL/minute: 200 mg every 12 hours
    • ESRD patients on hemodialysis: 200 mg every 12 hours; dose given after hemodialysis on dialysis days
  • Pediatric
    • ≥ 2 months to < 18 years of age
      • CrCl > 50 mL/minute/1.73 m²: No adjustment necessary
      • CrCl ≤ 50 mL/minute/1.73 m²: Insufficient data, use with caution, dosing adjustment may be necessary
    • ≥ 18 years of age - same as adult dosing
• Hepatic Dosing
  • Adult
    • No dosage adjustment in manufacturer's labeling. Has not been studied.
  • Pediatric
    • No dosage adjustment in manufacturer's labeling. Has not been studied.

• Allergy to class/drug

• Half-life:
  • 1.6 ± 0.38 hours (single dose), 2.66 ± 0.4 hours (multiple doses)
• Metabolism:
• Excretion:
  • Urine 88%, Feces 6%
• Mechanism of Action:
  • Inhibits bacterial cell wall synthesis by binding to penicillin-binding proteins

Ceftaroline: Drug information. UpToDate. www.uptodate.com. Accessed April 1, 2019.