Burkholderia cepacia

Background

  • Infection occurs in patients who are immune suppressed or those with chronic lung disease (e.g. cystic fibrosis)
  • Often resistant to multiple antibiotics

Antibiotic Sensitivities[1]

Category Antibiotic Sensitivity
PenicillinsPenicillin GR
Penicillin VR
Anti-Staphylocccal PenicillinsMethicillinR
Nafcillin/OxacillinR
Cloxacillin/Diclox.R
Amino-PenicillinsAMP/AmoxR
Amox-ClavR
AMP-SulbR
Anti-Pseudomonal PenicillinsTicarcillinR
Ticar-ClavX1
Pip-TazoX1
PiperacillinX1
CarbapenemsDoripenemI
ErtapenemR
ImipenemR
MeropenemS
AztreonamR
FluroquinolonesCiprofloxacinR
OfloxacinR
PefloxacinX1
LevofloxacinX1
MoxifloxacinR
GemifloxacinX1
GatifloxacinR
1st G CephaloCefazolinR
2nd G. CephaloCefotetanR
CefoxitinR
CefuroximeR
3rd/4th G. CephaloCefotaximeI
CefizoximeI
CefTRIAXoneI
CeftarolineR
CefTAZidimeS
CefepimeI
Oral 1st G. CephaloCefadroxilR
CephalexinR
Oral 2nd G. CephaloCefaclor/LoracarbefR
CefproxilR
Cefuroxime axetilR
Oral 3rd G. CephaloCefiximeR
CeftibutenS
Cefpodox/Cefdinir/CefditorenX1
AminoglycosidesGentamicinR
TobramycinR
AmikacinR
ChloramphenicolS
ClindamycinR
MacrolidesErythromycinR
AzithromycinR
ClarithromycinR
KetolideTelithromycinR
TetracyclinesDoxycyclineR
MinocyclineI
GlycylcyclineTigecyclineI
DaptomycinR
Glyco/LipoclycopeptidesVancomycinR
TeicoplaninR
TelavancinR
Fusidic AcidR
TrimethoprimS
TMP-SMXS
Urinary AgentsNitrofurantoinR
FosfomycinX1
OtherRifampinR
MetronidazoleR
Quinupristin dalfoppristinX1
LinezolidR
ColistimethateR

Key

  • S susceptible/sensitive (usually)
  • I intermediate (variably susceptible/resistant)
  • R resistant (or not effective clinically)
  • S+ synergistic with cell wall antibiotics
  • U sensitive for UTI only (non systemic infection)
  • X1 no data
  • X2 active in vitro, but not used clinically
  • X3 active in vitro, but not clinically effective for Group A strep pharyngitis or infections due to E. faecalis
  • X4 active in vitro, but not clinically effective for strep pneumonia

Table Overview

See Also

References

  1. Sanford Guide to Antimicrobial Therapy 2014
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