Baclofen toxicity

Background
  • Indications include MS, muscle spasticity pain
  • GABAb receptor agonist
  • Most excretion is renal

Clinical Features
  • nausea and vomiting
  • Drowziness, dizziness
  • Seizures, delirium, altered mental status, coma
  • Bradycardia, hypotension OR hypertension, respiratory compromise
  • Hypothermia

Differential Diagnosis


Evaluation
  • Diagnosis of exclusion

Management
  • Activated charcoal for recent ingestion
  • Supportive care:
    • IV fluids, respiratory care
    • Vasopressors for persistent hypotension
    • Benzodiazepines for seizures
  • Hemodialysis for very severe toxicity

Disposition


See Also


References
    • Jung, M. “Baclofen Overdoses”. Maryland Poison Center, University of Maryland School of Pharmacy. www.mdpoison.com Accessed April 29th, 2014.
    • Nicola Y Leung, Ian M Whyte, Geoffrey K Isbister Baclofen overdose: defining the spectrum of toxicity. Emerg Med Australas: 2006, 18(1);77-82
    This article is issued from Wikem. The text is licensed under Creative Commons - Attribution - Sharealike. Additional terms may apply for the media files.