Amoxicillin
General
- Type: Amino-Penicillin
- Dosage Forms: oral solution, capsule, tablet, chewable tablet, extended release tablet
- Dosage Strengths: oral solution: 125, 200, 250, 400mg/5 mL; capsule: 250, 500mg; tablet: 500, 875mg; chewable tablet: 125, 250mg; extended release tablet: 775mg
- Routes of Administration: PO
- Common Trade Names: Amoxil; Moxatag, Trimox
Adult Dosing
General
- 500-875mg PO q12
Strep Pharyngitis
- 1000mg PO q24h x 10 days
Otitis Media
- 1000mg PO q8h x 10 days
Sinusitis
- 1000mg PO q8h x 10 days
Dental Abscess
- 1000mg PO x 1, then 500mg PO q8h x 3 days
- If I&D
Chlamydial Cervicitis/Urethritis
- 500mg PO q8h x 7 days
- For pregnant patients
Lyme Disease
- 500mg PO q8h x 14-21 days
Salmonella
Not 1st line treatment
- Acute
- Immunocompetent
- 500mg PO q8h x 3-7 days
- Immunocompromised
- 1000mg PO q8h x 3-14 days
- Immunocompetent
- Chronic carrier
- 1000mg PO q8h x 3 months
Typhoid Fever
Not 1st line treatment
- 50-100mg/kg/day PO divided q6-8h x 14 days
- First Dose: 12.5mg-33.3mg/kg PO x 1
Pediatric Dosing
General
- <3mo: 20-30mg/kg/day PO divided q12h
- First Dose: 10-15mg/kg PO x 1
- Max: 30mg/kg/day
- >3mo: 25-45mg/kg/day PO divided q12h
- First Dose: 12.5-22.5mg/kg PO x 1
- Max: 875mg/dose
Otitis Media
- <2 months
- 30mg/kg/day PO divided q12h x 10 days
- First Dose: 15mg/kg PO x 1
- 2 months - 5 years
- 80-90mg/kg/day PO divided q12h x 10 days
- First Dose: 40-45mg/kg PO x 1
- Max: 1000mg/dose
- 6-12 years
- 80-90mg/kg/day PO divided q12h x 5-10 days
- First Dose: 40-45mg/kg/day PO x 1
- Max: 1000mg/dose
Community Acquired Pneumonia
- 90mg/kg/day PO divided q12h x 5-10 days
- First Dose: 45mg/kg PO x 1
- Max
- 3 months - 4 years: 500mg/dose
- >5 years: 4000mg/day
- Max
Strep Pharyngitis
- 50mg/kg Po q24h x 10 days
- Max: 1000mg/day
Sinusitis
- 90mg/kg/day PO divided q8-12h x 10 days
- Max: 1000mg/dose
H. pylori
- 50mg/kg/day PO divided BID x 7-14 days
- Max: 2000mg/day
Early Lyme Disease
- 50mg/kg/day PO divided q8h x 14-21 days
- First Dose: 16.6mg/kg PO x1
- Max: 500mg/dose
Salmonella (>3mo)
- 50-100mg/kg/day PO divided q8-12h
- Acute: x 3-7 days
- Acute Immunocompromised: 10-14 days
- Chronic: 3 months
Typhoid Fever (>3mo)
Not 1st line treatment
- 50-100mg/kg/day PO divided q6-8h x 14 days
Special Populations
- Pregnancy Rating: B
- Lactation: Use caution
- Renal Dosing
- Adult
- Pediatric
- Hepatic Dosing
- Adult
- Pediatric
Contraindications
- Allergy to class/drug
Adverse Reactions
Serious
- Anaphylaxis
- Hypersensitivity vasculitis
- SJS/TEN
- Pseudomembranous colitis
Common
- Diarrhea, nausea/vomiting
- Rash
- Headache
- AST/ALT elevation
- Mucocutaneous candidiasis
- Serum sickness-like reactions
- Anemia, leukopenia, thrombocytopenia, eosinophilia
- Hyperactivity, anxiety, insomnia, confusion behavioral changes
- Tooth discoloration
Pharmacology
- Half-life: 3.7 hr (neonates), 1-2 hr (infants and children), 0.7 - 1.4 hr (adults)
- Metabolism: Hepatic
- Excretion: Urine
- Mechanism of Action: Inhibits bacterial cell wall synthesis
Antibiotic Sensitivities[1]
Key
- S susceptible/sensitive (usually)
- I intermediate (variably susceptible/resistant)
- R resistant (or not effective clinically)
- S+ synergistic with cell wall antibiotics
- U sensitive for UTI only (non systemic infection)
- X1 no data
- X2 active in vitro, but not used clinically
- X3 active in vitro, but not clinically effective for Group A strep pharyngitis or infections due to E. faecalis
- X4 active in vitro, but not clinically effective for strep pneumonia
See Also
References
- Sanford Guide to Antimicrobial Therapy 2014
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